No specific interaction studies have been conducted with AERIUS D-12 Tablets. However, in clinical pharmacology studies in healthy volunteers, there were no clinically relevant changes in the safety profile of desloratadine when co-administered with erythromycin, ketoconazole, azithromycin, fluoxetine and cimetidine as assessed by electrocardiographic parameters (including the corrected QT interval), clinical laboratory tests, vital signs and adverse events (see Table 2).
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The antihypertensive effects of beta-adrenergic blocking agents, methyldopa, mecamylamine, reserpine, and veratrum alkaloids may be reduced by sympathomimetics.
Increased ectopic pacemaker activity can occur when pseudoephedrine is used concomitantly with digitalis.